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Taking Desvenlafaxine with other drugs that make you sleepy or slow your breathing can increase these effects. Ask your doctor before taking Desvenlafaxine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety or seizures.

Many drugs can interact with desvenlafaxine. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with Desvenlafaxine, especially:

  • any other antidepressant;
  • a blood thinner such as warfarin, Coumadin;
  • a diuretic or "water pill";
  • lithium;
  • midazolam;
  • imatinib;
  • St. John's wort;
  • tryptophan (sometimes called L-tryptophan);
  • an antibiotic--clarithromycin, telithromycin;
  • antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;
  • heart medication--nicardipine, quinidine;
  • hepatitis C medications--boceprevir, telaprevir;
  • HIV/AIDS medication--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir;
  • migraine headache medication--sumatriptan, rizatriptan, and others; or
  • pain medication--fentanyl or tramadol.

This list is not complete and many other drugs can interact with Desvenlafaxine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

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